KUANG PEIGEN

Kuang Peigen (1924-)

Dr. Kuang Peigen, a native of Wuxi, Jiangsu Province, was born in 1924 in an aristocratic family of traditional Chinese medicine. In 1949, she graduated from the state-run Shanghai Medical College and she has been practising in an acupuncture clinic since the 1950s. She summarized "Five Necessities in Acupuncture Stimulation" and published more than twenty articles on acupuncture research. She has won nineteen achievement awards in scientific research. At present she is the director and professor of the brain department of the Military Doctors’ Refresher College of the People’s Liberation Army of China, a councillor of the Society of Neurology and Psychiatry, CMA, and vice-chairman of the Beijing Branch of the Chinese Medical Association. (source : Essentials of Contemporary Chinese Acupuncturist Clinical Experience. Beijing : Foreign Languages.1989)

1- gera: 4972/di/cg
 [RECHERCHES PRELIMINAIRES SUR LES RELATIONS ENTRE CEPHALEES ET CONDUCTIBILITE ELECTRIQUE DES POINTS D’ACUPUNCTURE DE L’OREILLE]. KUANG PEIGEN ET AL. advances in acupuncture and acupuncture anaesthesia,beijing. 1980;292:295 (eng).
 Etude chez 42 sujets avec céphalées comparés à 30 sujets sains. Etude de la conductibilité électrique au niveau des points auriculaires occiput et front. La conductibilité est plus grande en cas de céphalée. Il existe une relation entre la valeur de la conductibilité et l’intensité de la céphalée. Une valeur de 100 micro-A est un bon critère de diagnostic. Il existe une relation entre la valeur de la conductance et l’efficacité thérapeutique du
 
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 [EFFECT OF ACUPUNCTURE ON PLASMA DOPAMINE BETA-HYDROXYLASE IN PATIENTS WITH HEADACHE]. KUANG PEIGEN ET AL. acupuncture research. 1982;7(1):43 (chi*).
 L’activité de la DBH est enregistrée avant et 15 minutes après le traitement ainsi que la tension artérielle et la fréquence cardiaque. L’activité de DBH tend à diminuer chez les patients avec amélioration de la céphalée et à augmenter chez les patients sans amélioration. Mais la différence n’est pas significative. Par contre on observe une différence significative chez les patients amélioré quant à une diminution de la TA et de la fréquence cardiaque. Ceci suggère que le système sympathique est une composante du mécanisme analgésique de
 
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 [A STUDY ON THE RELATIONSHIP BETWEEN THE EFFECTIVENESS OF ELECTROACUPUNCTURE AND ERYTHROCYTE ACETYLCHOLINESTERASE ACTIVITY IN *]. KUANG PEIGEN ET AL. acupuncture research. 1983;8(3):224 (chi*).
 Etude chez 53 patients traités par électroacupuncture. Un effet positif est observé chez 45. Chez ces patients on observe une diminution de l’activité AChE et une augmentation de la microcirculation. L’action de l’acupuncture passe par une mise en jeu du parasympathique.
 
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 [EFFET PROTECTEUR DE RADIX SALVIAE MILTIORRHIZAE COMPOSITA DANS L’ISCHEMIE CEREBRALE]. KUANG PEIGEN ET AL. journal of tcm. 1983;3(3):193-98 (eng).
 La plante est utilisée dans les maladies vasculaires cérébrales en tant qu’activeur de la circulation et levée de stase, mais n’a pas fait l’objet d’étude controlée et randomisée. L’étude expérimentale animale montre une action protectrice significative, éventuellement due aux monoamines cérébrales.
 
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 [RELATIONS ENTRE L’EFFET THERAPEUTIQUE DE L’AURICULOPUNCTURE ET LE TAUX D’ACETYLCHOLINESTERASE]. KUANG PEIGEN ET AL. journal of traditional chinese medicine. 1984;25(1):55 (chi).
 
 
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 EFFECT OF MERIDIAN DIALECTISM IN PATIENTS WITH ENDOGENOUS TYPE OF HEADACHE ON PLASMA DOPAMINE-BETA-HYDROXYLASE. KUANG PEIGEN ET AL. second national symposium on acupuncture and moxibustion,beijing. 1984;:39 (eng).
 
 
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 RELATIONSHIP BETWEEN THERAPEUTIC EFFECT OF ELECTROACUPUNCTURE IN PATIENTS WITH HEADACHE AND ERYTHROCYTE ACETYLCHOLINESTERASE*. KUANG PEIGEN ET AL. second national symposium on acupuncture and moxibustion,beijing. 1984;:416 (eng).
 
 
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 [ETUDES SUR QUINGYANGSHEN (RACINE DE CYNANCHUM OTOPHYLLUM). (3) EFFETS SUR LA CONCENTRATION EN ACETYLCHOLINE DANS LE CERVEAU *]. KUANG PEIGEN ET AL. journal of tcm. 1985;5(4):267-70 (chi).
 
 
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 STUDIES ON QINGYANGSHEN (ROOT OF CYNANCHUM OTOPHYLLUM). KUANG PEIGEN ET AL. journal of traditional chinese medicine. 1985;5(3):191-4 (eng).
 
 
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 CEREBRAL INFARCTION IN A BILATERAL COMMON CAROTID ARTERY LIGATION MODEL PROTECTED BY RADIX SALVIAE MILTIORRHIZAE. KUANG PEIGEN ET AL. journal of tcm. 1986;6(2):121-4 (eng).
 
 
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 EFFECT OF HUOXUE HUAYU COMPOSITA ON TXB2 LEVELS IN ISCHEMICS RAT BRAIN. KUANG PEIGEN. journal of tcm. 1987;7(2):119 (eng).
 
 
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 MOTHERWORT AND CEREBRAL ISCHEMIA. KUANG PEIGEN ET AL. journal of tcm. 1988;8(1):37-40 (eng).
 
 
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 FIVE NECESSITES IN ACUPUNCTURE AND RESEARCH ON THEIR MECHANISM. KUANG PEIGEN. essentials of contemporary chinese acupuncturists’ clinical experiences, foreign lang. 1989;:106-19 (eng).
 
 
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 THE EFFECT OF RADIX SALVIAE MILTIORRHIZAE ON VASOACTIVE INTESTINAL PEPTIDE IN CEREBRAL ISCHEMIA : AN ANIMAL EXPERIMENT. KUANG PEIGEN ET AL. journal of traditional chinese medicine. 1989;9(3):203-06 (eng).
 
 
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 EFFECTS OF HEADACHE AND ERYTHROCYTE ACETYLCHOLINESTERASE BY APPLYING BEAN-PRESSING ON EAR-POINTS AND BLOODLETTING FROM APEX AURICULAE. KUANG PEIGEN ET AL. international journal of clinical acupuncture. 1990;1(2):127-30 (eng).
 PA Subcortex et Shen Men, associé à Frontal, Temporal ou Occipital en fonction de la topographie de la douleur. PA Apex.Mise en place de Semen Vaccariae et saignée (1 à 2 gouttes) du point Apex. Patients vus en crise : disparition des douleurs ou amélioration immédiate dans 61,8% des cas.
 
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 THE INVESTIGATION OF ANTIEPILEPTIC ACTION OF QINGYANGSHEN (QYS)- EFFECT OF QYS ON THE CONCENTRATIONS OF NEUROPEPTIDES IN RAT BRAIN. KUANG PEIGEN ET AL. journal of traditional chinese medicine. 1991;11(1):40-6 (eng).
 
 
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 THE EFFECT OF RADIX SALVIAE MILTIORRHIZAE (RSM) ON SUBSTANCE P IN CEREBRAL ISCHEMIA. ANIMAL EXPERIMENT. KUANG PEIGEN ET AL. journal of traditional chinese medicine. 1991;11(2):123-27 (eng).
 
 
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 RICERCA SULL’AZIONE ANTIEPILETTICA DEL QINGYANGSHEN (QYS) EFFETO DI QYS SULLA CONCENTRAZIONE DEI NEUROPEPTIDI NEL CERVELLO DI RATTO. KUANG PEIGEN ET AL. rivista italiana di medicina tradizionale cinese. 1991;3:65-8 (ita).
 
 
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 EFECTOS DE LA RADIX SALVIAE MILTIORRHIZAE (RSM) SOBRE LA SUSTANCIA P EN LA ISQUEMIA CEREBRAL (EXPERIMENTACION ANIMAL). KUANG PEIGEN ET AL. revista de la medicina tradicional china. 1991;2(1):55-58 (esp).
 Se determinaron los niveles de sustancia P (SP) en el cerebro de 64 ratas. Se practicó una ligadura bilateral de la carótida común en 49 ratas. Media hora antes de la ligadura se administraron 10 gr. /kg. de RSM a 25 ratas y el mismo volumen de suero salino a 24 ratas que servían de control. Se realizó una operación de simulacro en 15 ratas. Las ratas fueron rápidamente decapitadas media hora y tres horas después de la isquemia cerebral. Se determinaron los niveles de SP en corteza cerebral, núcleo caudado y tronco cerebral. El nivel de SP en el núcleo caudado de los animales control del grupo de 3 horas era signiIicativamente menor que en los del grupo de media hora y que en los del grupo de la operación simulada respectivamente. No se encontraron diferencias significativas entre el grupo tratado con RSM y el de operación simulada. Los niveles de SP seguían la siguiente distribución: Tronco cerebral > núcleo caudado > corteza cerebral. Los resultados preliminares sugieren que la SP puede estar implicada en los mecanismos Iisiopatológicos de la isquemia cerebral y que la RSM puede atenuar la
 
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 INVESTIGACION SOBRE LA ACCION ANTIEPILEPTICA DE LA RAIZ CYNANCHUM OTOPHILLUM Y SU INFLUENCIA SOBRE LA CONCENTRACION EN EL CEREBRO DE LA RATA. KUANG PEIGEN ET AL. revista de la medicina tradicional china. 1991;4:53-58 (esp).
 Se determinaron las concentraciones de neuropéptidos centrales, somatostatina (SO) y sustancia P (SP) en las diferentes regiones del cerebro de ratas macho jóvenes tras la administración prolongada de los siguientes anticonvulsivantes: Qingyangshen (QYS), difenilhidantoína (DPH) y carbamazepina (CBZ). Los resultados fueron comparados con el modelo de convulsiones inducidas con pentilenetetrazol (PTZ) y con los controles tratados con suero salino. No se encontraron efectos del QYS sobre las concentraciones de SO y SP en los grupos de ratas de 4 y 8 semanas de edad. La DPH y el PTZ aumentaban los niveles de SO en el cerebro medio del grupo de ratas de 4 semanas de edad. DPH, CBZ y PTZ también aumentaban los niveles de SP en la corteza cerebral, núcleo estriado y tronco cerebral del grupo de ratas de 8 semanas de edad. Nuestros resultados indican que los neuropéptidos centrales, SO y SP están implicados en los procesos de epilepsia y antiepilepsia. El hecho de que el QYS no influya sobre los niveles de SO y SP tras una administración prolongada sugiere que el mecanismo anliconvulsivante del QYS puede diferir del de la DPH y CBZ, por ejemplo, puede no estar debido a su efecto
 
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 EFFETTO DI RADIX SALVIAE MILTIORRHIZAE (RSM) SULLA SOSTANZA P NELL’ISCHEMIA CEREBRALE ESPERIMENTO SU ANIMALI. KUANG PEIGEN ET AL. rivista italiana di medicina tradizionale cinese. 1991;6:80-2 (ita).
 
 
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 EFFECT OF RADIX SALVIAE MILTIORRHIZAE ON EAA AND IAA DURING CEREBRAL ISCHEMIA IN GERBILS : A MICRODIALYSIS STUDY. KUANG PEIGEN ET AL. journal of traditional chinese medicine. 1994;14(1):45-50 (eng).
 The concentrations of amino acids (AA), stroke index and infarct area were determined in 26 gerbils which were divided into 3 groups: RSM-treated (n = 8), Saline-treated (n = 10) and sham-operated (n = 8). The levels of AA were measured with microdialysis technique in cerebral cortex. The concentrations of neurotransmitter AA, as Glu and GABA and Asp, were significantly increased during the first 60 min after CCA ligation, while the concentrations of non-neurotransmitter AA, as Thr and Ser, had no significant changes. In RSM-treated gerbils, the level of Glu was significantly lower than that of the saline-treated, but the GABA in RSM-treated was significantly higher than that of the saline-treated. The ratio of Glu/GABA was significantly decreased after ischemia. The RSM could improve the reduction of ratio of Glu/GABA during 0-30 min and 91-120 min after cerebral ischemia. There were statistically significant decrease in terms of stroke index in RSM-treated group when compared with saline- treated group at 24 h and 16 h after CCA ligation respectively. The RSM has a tendency to decrease the size of infarct area, but no statistical difference. The results suggest that the neurotransmitter AA involve in the pathophysiological procedures of cerebral ischemia and the RSM can attenuate dysfunctions of EAA and IAA. Furthermore, the results also imply that there may be an alternate way to treat cerebral ischemia by inhibiting the presynaptic releasing of Glu and stimulating the releasing of GABA.
 
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 DIMOSTRAZIONE DEL MIGLIORAMENTO DEL DANNO CELLULARE A CARICO DEL CEVELLO DI RATTO CON L’USO DI RADIX SALVIAE MILTIORRHIZAE. KUANG PEIGEN ET AL. rivista italiana di medicina tradizionale cinese. 1994;55(1):81-2 (ita).
 Dopo legatura della arteria cerebrale media (MCA) e dell’arteria carotide comune (CCA) sono state osservate modificazioni a carico della somatostatina (SS), della immunocitologia e della morfologia cellulare. I risultati sono stati i seguenti : 1 . diminuzione dell’immunoreattività alla somatostatina (SS) nella cortecciadi destra 3 ore dopo la legatura della MCA destra rispetto alla corteccia di sinistra e al gruppo sottoposto a pseudointervento. Non ci sono state differenze tra il gruppo trattato con RSM (radix Salviae miltiorrhizae) e il gruppo trattato con soluzione salina. 2. Modificazioni ischemiche delle cellule della corteccia, dell’ippocampo e del nucleo caudato a 3 ore dalla legatura della CCA. Le modificazioni comprendevano restringimento e condensazione del pericarion, picnosi nucleare ed eosinifilia citoplasmatica. Le modificazioni ischemiche erano più marcate nel gruppo trattato con soluzione salina rispetto a gruppo trattato con RSM. Gli esperimenti condotti indicano che
 
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 EFFECT OF RADIX SALVIAE MILTIORRHIZAE ON NITRIC OXIDE IN CEREBRAL ISCHEMIC-REPERFUSION INJURY. KUANG PEIGEN ET AL. journal of tcm. 1996;16(3):224-7 (eng).
 
 
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 RADIX SALVIAE MILTIORRHIZAE TREATMENT RESULTS IN DECREASED LIPID PEROXIDATION IN REPERFUSION INJURY. KUANG PEIGEN ET AL. journal of tcm. 1996;26(2):138-42 (eng).
 
 
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 EFFECT OF RADIX SALVIAE MILTIORRHIZAE ON EXTRACELLULAR ADENOSINE AND EVALUATION OF ITS PROTECTIVE EFFICACY IN ISCHEMIC REPERFUSION RAT – MICRODIALYSIS, HPLC AND HISTOPATHOLOGIC STUDIES. KUANG PEIGEN ET AL. journal of tcm. 1997;17(2):140-7 (eng).
 
 
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 EFFETTO DI RADIX SALVIAE MILTIORRHIZAE SULL’ADENOSINA EXTRACELLULARE E VALUTAZIONE DELLA SUA EFFICACIA PROTETTIVA NEL RATTO ISCHEMICO RIPERFUSO-STUDI CON MICRODIALISI, HPLC E ISTOPATOLOGICI. KUANG PEIGEN ET AL. rivista italiana di medicina tradizionale cinese. 1998;72(2):75-80 (ita).
 Furono studiati gli effetti di Radix Salviae miltiorrhizae (RSM) sull’adenosina extracellulare (Ade) e i suoi metaboliti inosina (Ino), ipcxantina (Hypo) e xantina (Xan) mediante tecniche di microdialisi e HPLC durante ischemia-riperfusione cerebrale indotta da occlusione di 4 vasi nel cervello di ratto. Fu eseguito un esame istologico dell’ippocampo 6 ore dopo la riperfusione. L’adenosina nel ECF (fluido extracellulare) e i su
i metaboliti furono sottoposti a confronto tra i controlli (n=6) e i ratti trattati con RSM (n=6). I1 livello basale di Ade e la liberazione dei suoi metaboliti non erano molto influenzati dal pretrattamento con RSM, né significativamente differenti dagli animali sottoposti a intervento simulato (n=6). Ade e i suoi metaboliti aumentarono in modo spettacolare dopo l’ischemia, e al termine della riperfusione Ade scese a un livello prossimo al basale, mentre i suoi metaboliti rimasero elevati. Negli animali trattati con RSM, la tendenza delle variazioni di Ade e dei suoi metaboliti fu esattamente la stessa dei controlli, ma la grandezza delle variazioni risulto significativamente inferiore nei diversi intervalli di rilevamento. Negli animali sottoposti a intervento simulato, non vennero osservate variazioni a intervalli di rilevamento diversi sia durante I’ischemia (30 min.) che durante la riperfusione (60 min.). I reperti istopatologici dimostrarono che it pretrattamento con RSM risultava in una migliore conservazione istologica sia qualitative che quantitative delle cellule piramidali nel settore CA1 riperfuso dopo la postischemia. Questi risultati indicarono che RSM protegge dai danni dell’ischemiariperfusione
 
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 BATROXOBIN AGAINST ANOXIC DAMAGE OF RAT HIPPOCAMPAL NEURONS IN CULTURE: MORPHOLOGICAL CHANGES AND HSP70 EXPRESSION. LIU JUN, KUANG PEIGEN, WU WEIPING ET AL. journal of tcm. 2001;21(3):215 (eng*).
 
 
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 BATROXOBIN AGAINST ANOXIC DAMAGE OF RAT HIPPOCAMPAL NEURONS IN CULTURE: MORPHOLOGICAL CHANGES AND HSP70 EXPRESSION. LIU JUN, KUANG PEIGEN, WU WEIPING ET AL. journal of tcm. 2003;21(3):215 (eng*).
 Batroxobin , the thrombin-like enzyme is used for therapeutic defibrination. We have found that batroxobin has good therapeutic effect in ischemic reperfusion rats and clinical practices in vivo. But we have not studied the neuroprotective effect of batroxobin on anoxic hippocampal neurons in vitro. The purpose of this study was to obtain further information on the mechanism of the batroxobin-induced neuroprotection and examine the neuroprotective effect on neurons exposed to anoxia. The effect of batroxobin on anoxic damages in cultured- hippocampal neurons of neonatal rats was investigated by using morphological changes and heat shock protein 7OKd (Hsp70) immunoreactive expression as indicators. The results indicate that batroxobin, besides its defibrination, may have a direct neuroprotective effect on anoxic damage of hippocampal neurons.